Cardiomyocyte–myofibroblast contact dynamism is modulated by connexin‐43
نویسندگان
چکیده
منابع مشابه
Feedback control in active sensing: rat exploratory whisking is modulated by environmental contact.
Rats sweep their facial whiskers back and forth to generate tactile sensory information through contact with environmental structure. The neural processes operating on the signals arising from these whisker contacts are widely studied as a model of sensing in general, even though detailed knowledge of the natural circumstances under which such signals are generated is lacking. We used digital v...
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The present study demonstrated that friction cues for target motion affect time-to-contact (TTC) estimation. A circular target moved in a linear path with a constant velocity and was gradually occluded by a static rectangle. The target moved with forward and backward spins or without spin. Observers were asked to respond at the time when the moving target appeared to pass the occluder. The resu...
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Macrophages that lack connexin43 (Cx43), a gap junction protein, have been reported to exhibit dramatic deficiencies in phagocytosis. In this study, we revisit these findings using well-characterized macrophage populations. Cx43 knockout (Cx43(-/-)) mice die soon after birth, making the harvest of macrophages from adult Cx43(-/-) mice problematic. To overcome this obstacle, we used several stra...
متن کاملUbiquitin protein ligase Nedd4 binds to connexin43 by a phosphorylation-modulated process.
Connexin43 is degraded by the proteasomal as well as the lysosomal pathway with ubiquitin playing a role in both degradation pathways. So far, no ubiquitin protein ligase has been identified for any of the connexins. By using pull-down assays, here we show binding of a ubiquitin protein ligase, Nedd4, to the C-terminus of connexin43. This observation was confirmed in vivo by coimmunoprecipitati...
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Primary cultures of rat brain astrocytes were used to examine the uptake of the glucose analogue, 2-deoxy-d-glucose (2-DOG). 2-DOG competes with glucose for uptake, indicating that both are transported by the same carrier system. Extracellular K + at 1 1 . 9 m ~ increased the uptake of 2-DOG at 2-DOG concentrations greater than 100 p ~ . Uptake appears Na+-dependent only at high concentrations ...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2019
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fj.201802740rr